| Best Record |
| 5-1-0 (1967, 1969) |
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| Worst Record |
| 0-5-0 (1981) |
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| Most Points Scored |
| Memphis - 69 vs Louisville, 1969 |
| Opponent - 56, Louisville, 2004 & Houston, 2010 |
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| Highest Combined Score |
| 107 pts., 55-52, 3OT win over SMU, 2007 |
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| Lowest Combined Score |
| 3 pts., 3-0 loss to Ole Miss, 1999 |
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| Longest Run from Scrimmage |
| Memphis - 92 yards by Herb Covington vs Cincinnati, 1966 |
| Opponent - 84 yards by Mickey Collins, Wichita State, 1978 |
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| Longest Pass Completion |
| Memphis - 94 yards by Lloyd Patterson to Earnest Gray vs Houston, 1978 |
| Opponent - 85 yards by Erik Ainge to Robert Meachem, Tennessee, 2006 |
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| Longest Interception Return |
| Memphis - 91 yards by Bob Orians vs Southern Miss, 1977 |
| Opponent - 99 yards by Izell McGill, Mississippi State, 1996 (intercepted fumble) & by Dustin Mouzon, Ole Miss, 2007 |
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| Longest Kickoff Return |
| Memphis - 98 yards by Jerry Harris vs Southern Miss, 1983 |
| Opponent - 100 yards by Maurice Nelson, Tulane, 1985 |
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| Longest Punt Return |
| Memphis - 94 yards by Keith Wright vs Louisville, 1975 |
| Opponent - 85 yards by Morris Letcher, East Carolina, 1992 |
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| Longest Field Goal |
| Memphis - 53 yards by Stephen Gostkowski vs Marshall, 2005 |
| Opponent - Franco Grilla 50 yards, UCF, 1990 |
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| Most Yards Rushing by an Individual |
| Memphis - 262 yards by DeAngelo Williams vs Houston, 2004 |
| Opponent - 301 yards by Chris Johnson, East Carolina, 2007 |
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| Most Yards Rushing by a Team |
| Memphis - 507 yards vs Tulsa, 1969 |
| Opponent - 491 yards, East Carolina, 2007 |
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| Fewest Yards Rushing by a Team |
| Memphis - minus 13 yards vs Texas A&M, 1979 |
| Opponent - minus 4 yards, Ole Miss, 1993 |
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| Most Yards Passing by an Individual |
| Memphis - 416 yards, Martin Hankins vs East Carolina, 2007 |
| Opponent - 431 yards by Jordan Palmer, UTEP, 2005 |
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| Most Yards Passing by a Team |
| Memphis - 416 yards vs East Carolina, 2007 |
| Opponent - 431 yards, UTEP, 2005 |
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| Fewest Yards Passing by a Team |
| Memphis - minus 3 yards vs Marshall, 2005 |
| Opponent - 14 yards, Southern Miss, 1981 |
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| Most Passing Attempts by an Individual |
| Memphis - 60 by Martin Hankins vs ECU & Ole Miss, 2007 |
| Opponent - 61 by Marquel Blackwell, USF, 2001 |
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| Most Passing Attempts by a Team |
| Memphis - 61 vs Ole Miss, ECU & SMU, 2007 |
| Opponent - 62 by USF, 2001 |
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| Most Pass Completions by an Individual |
| Memphis - 41 by Martin Hankins vs Ole Miss, 2007 |
| Opponent - 35 by Marcus Crandell, East Carolina, 1994 & by Justin Willis, SMU, 2007 |
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| Most Pass Completions by a Team |
| Memphis - 41 vs Ole Miss, 2007 |
| Opponent - 36 by East Carolina, 1994 |
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| Most Pass Receptions by an Individual |
| Memphis - 13 by Maurice Avery vs UAB, 2003 |
| Opponent - 14, Chris Penn, Tulsa, 1993 |
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| Most Receiving Yards by an Individual |
| Memphis - 186 yards by Bob Sherlag vs Mississippi State, 1965 |
| Opponent - 208 yards, James Casey, Rice, 2008 |
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| Most Total Offense by an Individual |
| Memphis - 405 yards by Martin Hankins vs ECU, 2007 |
| Opponent - 489 yards by Justin Willis, SMU, 2007 |
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| Most Total Offense by a Team |
| Memphis - 659 yards vs Louisville, 1969 |
| Opponent - 651 yards by Houston, 2010 |
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| Most Combined Total Offense by Two Teams in a Game |
| 1,202 yards, Memphis (603) vs Louisville (599), 2004 |
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| Most Touchdowns by a Team in a Game |
| Memphis - 10 vs Louisville, 1969 |
| Opponent - 8, Tennessee, 1969; Louisville, 2004; East Carolina, 2007 & Houston, 2010 |
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| Most Points Scored by an Individual |
| Memphis - 24 by DeAngelo Williams vs Houston & Chattanooga, 2004 |
| Opponent - 24 by Michael Haddix, Mississippi St., 1982; James Jones, Mississippi St., 1978; Eric Shelton, Louisville, 2004 & Chris Johnson, ECU, 2007 |
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| Most Rushing Touchdowns by an Individual |
| Memphis - 4 by DeAngelo Williams vs Houston, 2004 |
| Opponent - 4, Michael Haddix, Mississippi State, 1982; James Jones, Mississippi State, 1978 & Chris Johnson, East Carolina, 2007 |
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| Most Rushing Touchdowns by a Team |
| Memphis - 7 vs North Texas St., 1971 |
| Opponent - 6 by Tennessee, 1969; Texas A&M, 1978 & East Carolina, 2007 |
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| Most Touchdown Passes by an Individual |
| Memphis - 5 by Danny Wimprine vs Murray State, 2002 |
| Opponent - 5 by David Piland, Houston, 2010 & Tyler Bray, Tennessee, 2010 |
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| Most Touchdown Passes by a Team |
| Memphis - 5 vs Louisville, 1969; Murray State, 2002 & SMU, 2007 |
| Opponent - 6 by Houston, 2010 |
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| Most Touchdown Receptions by an Individual |
| Memphis - 3 by five players (most recent Carlos Singleton vs SMU, 2007) |
| Opponent - 3 by Alama Matthews, Vanderbilt, 1982, Roydell Williams, Tulane, 2004 & Emmanuel Sanders, SMU, 2007 |
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| Most Field Goals Made by an Individual |
| Memphis - 4 by Rusty Bennett vs North Texas State, 1977; Stephen Gostkowski vs Marshall, 2005 & Matt Reagan vs UAB, 2007 |
| Opponent - 4 by Jim Becksvoort, Tennessee, 1992 and Michael Torres, UCF, 2006 |
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| Most Points Kicking by an Individual |
| Memphis - 15 by Ryan White vs Cincinnati, 1998 |
| Opponent - 14 by Jim Becksvoort, Tennessee, 1992, Michael Torres, UCF, 2006 & Michael Palardy, Tennessee, 2010 |
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| Most Interceptions by an Individual |
| Memphis - 3 by Keith Simpson vs North Texas State, 1977, and Olie Cordell vs Mississippi State, 1965 |
| Opponent - 3 by Chris Donnelly, Vanderbilt, 1989 & J.R. Reed, USF, 2003 |
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| Most Interceptions by a Team |
| Memphis - 6 vs Tulsa, 1972 |
| Opponent - 5 by three teams (most recent Mississippi State, 2002) |
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| Most Interception Return Yardage by an Individual |
| Memphis - 95 yards by Marty Hammock vs Southern Miss, 1973 |
| Opponent - 124 yards by Shawn Ferguson, Cincinnati, 1998 (two interceptions) |
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| Most Punts by an Individual |
| Memphis - 13 by Hugh Owens vs Texas A&M, 1979 |
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| Most Punt Returns by an Individual |
| Memphis - 6 by Russell Copeland vs Cincinnati, 1992 |
| Opponent - 8 by Willie Gault, Tennessee, 1981 |
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| Most Punt Returns by a Team |
| Memphis - 8 vs Quantico, 1968 |
| Opponent - 13 by Texas A&M, 1979 |
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| Most Punt Return Yardage |
| Memphis - 133 by David Berrong vs Wichita State, 1968 |
| Opponent - 123 by Morris Letcher, East Carolina, 1992 |
